Manchester United midfielder Darren Fletcher returns from suspension for the clash at Eastlands. The Scotland skipper will almost certainly replace Paul Scholes in central midfield, where he may be joined by Darron Gibson.
Brazilian twins Fabio and Rafael Da Silva are also under consideration by Sir Alex Ferguson while Dimitar Berbatov is doubtful with a dead leg.
United manager Alex Ferguson has rotated his squad throughout this year's League Cup but will be tempted to play all his big guns against City, particularly having already gone out of the FA Cup in embarrassing fashion to League One Leeds United.